Enter inputs
To perform a meta-analysis of interventions:
  • Revise or replace the example data below as needed or
  • Upload a csv file formatted like these examples with dichotomous or continous outcomes.
    1st row is column names?
Required columns: 1) study name, 2) year, 3) PMID, 4) events of mean (SD) in intervention group, 5) total in intervention group, 6) events or mean (SD) in control group, 7) total in control group.
Optional columns for up to five cofactors
Separate columns with commas. Click here to add commas.
The initial data shown below is fictitious and is instructional.
Downs, 2012, 12345678, 50, 100, 50, 100, high-dose, Jones, 2013, 12345678, 50, 100, 50, 100, low-dose, Smith, 2014, 12345678, 50, 100, 50, 100, high-dose, Snead, 2015, 12345678, 50, 100, 50, 100, low-dose, Parks, 2016, 12345678, 50, 100, 50, 100, high-dose,
Meta-analysis settings

  
 
Example analyses

Teaching example 1: Soma (fictitious)

Fictitious example based on Brave New World
Before making the plot
  • Do you believe Soma will show a benefit when the studies are pooled?
Now, look at the plot
  • What does I2 indicate? (help)
Before making the plot
  • Do you believe Soma will show a benefit when the studies are pooled?
Now, look at the plot
  • What does I2 indicate? (help)

Teaching example 2: back pain treatment with tramadol

From PMID 29204613

Meta-analysis of binary outcomes

When pooled, is there a significant difference? What does i-squared suggest?
What does subgrouping reveal?

Meta-analysis of continuous outcomes

When pooled, is there a significant difference? What does i-squared suggest?
About standardized mean differences
The standardized mean difference (SMD) is:
SMD
In the interpretation of SMD:
  • 0.2 represents a small effect
  • 0.5 a moderate effect
  • > 0.8 a large effect
The 'standardization' allows pooling of different types of outcomes.

Meta-regression

What is the relationship between the final vitamin D level and the risk of fracture?
What is the relationship between the change in vitamin D level and the risk of fracture?
 
What is the relationship between reduction in mortality and the baseline serum lactate? How about with the morality in the control group?
 
Hint: if bad spacing between title/footer text and the plot, click 'png' file type in upper right of plot. Then after the image opens in a new browser window, alter the image's dimensions in the url of the window. Click here to see screen capture of an exampleopens in new window

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